4.8 Article

Cyano Diels-Alder and Cyano Ene Reactions. Applications in a Formal [2+2+2] Cycloaddition Strategy for the Synthesis of Pyridines

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 38, Pages 13203-13205

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja106901u

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Funding

  1. National Institutes of Health [GM 28273]
  2. Merck Research Laboratories
  3. Boehringer Ingelheim Pharmaceuticals
  4. Japan Society for the Promotion of Science (JSPS)

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Two metal-free, formal [2 + 2 + 2] cycloaddition strategies for the construction of polycyclic pyridine derivatives are described that proceed via pericyclic cascade mechanisms featuring the participation of unactivated cyano groups as enophile and dienophile cycloaddition partners.

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