Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 4, Pages 1252-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja908890q
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Funding
- Heeger presidential Chair Funds
- National Science Foundation [NSF-FMR 0602280]
- Institute for Collaborative Biotechnologies [DAAA19-03-D-0004]
- U.S. Army Research Office
- National Institutes of Health [EB007689-02]
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Water-soluble, cationic conjugated polymer binds single-stranded DNA with higher affinity than it binds double-stranded or otherwise folded DNA. This stronger binding results from the greater hydrophobicity of single-stranded DNA. Upon reducing the strength of the hydrophobic interactions, the electrostatic attraction becomes the important interaction that regulates the binding between the water-soluble conjugated polymer and DNA. The different affinities between the cationic conjugated polymer and various Forms of DNA (molecular beacons and its open state; single-stranded DNA and double-stranded DNA and single-stranded DNA and complex DNA folds) can be used to design a variety of biosensors.
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