Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 25, Pages 8532-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja102832f
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [20732003, 20872096]
- PCS1RT [1RT0846]
- National Basic Research Program of China [2010CB833300]
Ask authors/readers for more resources
The first catalytic enantioselective Roskamp reaction of alpha-alkyl-alpha-diazoesters with aromatic aldehydes was realized using a simple chiral N,N'-dioxide-scandium(III) complex. Remarkably, with 0.05 mol % catalyst, the reaction was performed well over a series of substrates, giving the desired products chemoselectively in excellent yields (up to 99%) and enantioselectivities (up to 98% ee) under mild conditions. This protocol provides a promising method for the synthesis of chiral alpha-alkyl-beta-keto esters and 1,3-diols.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available