4.8 Article

Hydroformylation Reaction of Alkylidenecyclopropane Derivatives: A New Pathway for the Formation of Acyclic Aldehydes Containing Quaternary Stereogenic Carbons

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 12, Pages 4066-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja100544c

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Funding

  1. State of Lower-Saxony and the Volkswagen Foundation, Hannover, Germany
  2. Israel Science Foundation
  3. Israel Academy of Sciences and Humanities [70/08]

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The rhodium-catalyzed hydroformylation reaction of methylene- and alkylidenecyclopropane derivatives proceeds under mild conditions to lead to the exclusive formation of linear aldehydes and the stereointegrity of the quaternary carbon center remains unaffected in the process.

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