4.8 Article

Iron-Catalyzed Suzuki-Miyaura Coupling of Alkyl Halides

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 31, Pages 10674-10676

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja103973a

Keywords

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Funding

  1. MEXT [18064006, 20037033, 2075003, 2175098]
  2. Japan Society for the Promotion of Science [213169]
  3. Tosoh Finechem
  4. Tosoh Corporations
  5. Grants-in-Aid for Scientific Research [23685020, 18064006, 20037033] Funding Source: KAKEN

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In the presence of novel iron(II) chloride-diphosphine complexes and magnesium bromide, lithium arylborates react with primary and secondary alkyl halides to give the corresponding coupling products in good to excellent yields. High functional group compatibility is also demonstrated in the reactions of substrates possessing reactive substituents, such as alkoxycarbonyl, cyano, and carbonyl groups.

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