Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 13, Pages 4510-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja100833h
Keywords
-
Categories
Funding
- MEXT, Japan [18002011]
- JSPS
- Grants-in-Aid for Scientific Research [18002011] Funding Source: KAKEN
Ask authors/readers for more resources
Iridium(III)-salen complexes were found to efficiently catalyze enantioselective carbene Si-H bond insertion. Highly enantioselective Si-H insertion with alpha-alkyl-alpha-diazoacetates (>= 97% ee) was achieved for the first time by using the iridium complex 4 {(aR,S), Ar = 4-TBDPSC(6)H(4)} bearing a concave-shaped salen ligand as the catalyst. Formation of a chiral silicon center was also achieved for the first time by the Si-H insertion into prochiral silanes: the reactions between prochiral silanes and tert-butyl alpha-diazopropionate in the presence of complex 5 {(aR,S), Ar = Ph} proceeded with high stereoselectivity (84-99% de, 94 -> 99% ee). The Si-H insertion into trisubstitued silanes with alpha-aryl-alpha-diazoacetates proceeded with almost complete enantioselectivity (>= 99% ee) by using complex 1 {(aR,R), Ar = Ph} as catalyst.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available