Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 23, Pages 7870-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja103472a
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Funding
- National Institutes of Health (NIGMS) [RO1GM3540, R01CA140296]
- DOD [W81XWH-09-1-0431]
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A unique alkene difunctionalization reaction that allows rapid construction of molecular complexity around the biologically relevant indole framework has been developed. The reaction proceeds with up to 87% yield, 99:1 er, and >20:1 dr. Evaluation of several of the compounds revealed promising anticancer activity against MCF-7 cells.
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