Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 14, Pages 5024-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja100503b
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Funding
- U.S. Environmental Protection Agency [GR-83237501]
- National Science Foundation [CBET-0617240]
- National Institutes of Health [U01ES016026]
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We report for the first time single-walled carbon nanotube (SWNT)-based chemiresistive affinity sensors for highly sensitive and selective detection of small and/or weakly charged or uncharged molecules using a displacement format. The detection of glucose, a small, weakly charged molecule, by displacement of plant lectin (concavalin A) bound to a polysaccharide (dextran) immobilized on SWNTs with picomolar sensitivity and selectivity over other sugars and human serum proteins is demonstrated as a proof of concept.
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