Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 6, Pages 1760-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja9097675
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Funding
- Robert A. Welch Foundation
- NIH-NIGMS [RO1-GM069445]
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Enantioselective transfer hydrogenation of gem-dibenzoate le in the presence of aromatic. alpha,beta-unsaturated, or aliphatic aldehydes 2a-i mediated by isopropyl alcohol and employing a cyclometalated iridium C,O-benzoate derived from allyl acetate, 4-cyano-3-nitrobenzoic acid, and (R)-SEGPHOS delivers products Of alkoxyallylation 3a-i, 4a, 4e, 4f, and 4i in good isolated yields (62-82%) with good to excellent diastereoselectivities (7:1 to 18:1 dr) and exceptional enantioselectivities (90-99% ee). This protocol provides an alternative to the Use of premetalated nucleophiles in carbonyl alkoxyallylation.
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