4.8 Article

Pd(II)-Catalyzed ortho-Trifluoromethylation of Arenes Using TFA as a Promoter

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 11, Pages 3648-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja909522s

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Funding

  1. National Science Foundation (NSF) [CHE-0910014]
  2. Scripps Research Institute
  3. Pfizer
  4. Alfred P. Sloan Foundation

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A Pd(II)-catalyzed C-H activation/trifluoromethylation of arenes with an electrophilic trifluoromethylation reagent using diverse heterocycle directing groups is reported. The presence of trifluoroacetic acid is crucial for this catalytic reaction.

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