Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 23, Pages 7860-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja102838n
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Funding
- Max Planck Society
- DFG Centre for Molecular Physiology of the Brain (DFG CMPB)
- AnpCyT
- CONICET
- UBA
- EU [03746511]
- Marie Curie Foundation
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We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of alpha-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of alpha-synuclein aggregation, a process associated with Parkinson's disease.
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