MRI Detection of VEGFR2 in Vivo Using a Low Molecular Weight Peptoid-(Gd)8-Dendron for Targeting

The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of similar to 48 mM(-1) s(-1) shown to enhance MR images of tumors grown in mice in vivo.