Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 8, Pages 2795-2801Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja910090v
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20689003, 19205021, 20117003, 20689001, 21659024]
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
- Mochida Memorial Foundation for Medical Pharmaceutical Research
- Sankyo Foundation of Life Science
- Grants-in-Aid for Scientific Research [20689003, 19205021, 21659024] Funding Source: KAKEN
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Reactive oxygen species (ROS) operate as signaling molecules under various physiological conditions, and overproduction of ROS is involved in the pathogenesis of many diseases. Therefore, fluorescent probes for visualizing ROS are promising tools with which to uncover the molecular mechanisms of physiological and pathological processes and might also be useful for diagnosis. Here we describe a novel fluorescence probe, FOSCY-1, operating in the physiologically favorable near-infrared region. The probe consists of two differentially ROS-reactive cyanine dyes connected by a linker; reaction of the more susceptible dye with ROS releases intramolecular fluorescence quenching of the less susceptible dye. We successfully applied this probe to detect ROS produced by HL60 cells and porcine neutrophils and for imaging oxidative stress in a mouse model of peritonitis.
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