Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 20, Pages 7119-7137Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja1009458
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Funding
- NCI
- Bristol-Myers Squibb
- NIH/NCI [CA134785]
- Skaggs Institute for Chemical Biology, Bristol-Myers Squibb
- Canadian Institutes of Health Research
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This report details the invention of a method to enable syntheses of psychotrimine (1) and the kapakahines F and B (2, 3) on a gram scale and in a minimum number of steps. Mechanistic inquiries are presented for the key enabling quaternization of indole at the C3 position by electrophilic attack of an activated aniline species. Excellent chemo-, regio-, and diastereoselectivities are observed for reactions with o-iodoaniline, an indole cation equivalent. Additionally, the scope of this reaction is broad with respect to the tryptamine and aniline components. The anti-cancer profiles of 1-3 have also been evaluated.
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