Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 46, Pages 16311-16313Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja1058907
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Funding
- Core Research for Evolutional Science and Technology (CREST) of JST
- MEXT, Japan
- Sumitomo foundation
- Grants-in-Aid for Scientific Research [21603008] Funding Source: KAKEN
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We herein report the real-time observation of G-quadruplex formation by monitoring the G-quadruplex-induced global change of two duplexes incorporated in a DNA nanoscaffold. The introduced G-rich strands formed an interstrand (3 + 1) G-quadruplex structure in the presence of K+, and the formed four-stranded structure was disrupted by removal of K. These conformational changes were visualized in a nanoscaffold in real-time with fast-scanning atomic force microscopy.
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