4.8 Article

Nanocomposites with Spatially Separated Functionalities for Combined Imaging and Magnetolytic Therapy

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 21, Pages 7234-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja102489q

Keywords

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Funding

  1. NIH [R01CA131797, R01CA140295]
  2. NSF [0645080]
  3. UW
  4. Nat. Sci. Council of Taiwan
  5. Div Of Chem, Bioeng, Env, & Transp Sys
  6. Directorate For Engineering [0645080] Funding Source: National Science Foundation

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Compact nanostructures with highly integrated functionalities are of considerable current interest to drug delivery, multimodality imaging, and electronic devices. A key challenge, however, is how to combine individual components together without interfering or sacrificing their original electronic and optical properties. Here, we demonstrate a new class of nanocomposites with spatially separated functionalities. We further demonstrate magnetic field modulated imaging and an innovative application of this technology in cancer cell treatment, magnetolytic therapy, based on magnetically controlled mechanical damage to cell membranes.

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