Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 3, Pages 1018-1022Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja9061272
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Funding
- NSF Center for Hierarchical Manufacturing at the University of Massachusetts [DMI-0531171]
- NIH [GM077173, AI0734257, CA095164, CA 105452]
- Department of Energy [DE-FG02-04ER46141]
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A family of conjugated fluorescent polymers was used to create an array for cell sensing. Fluorescent conjugated polymers with pendant charged residues provided multivalent interactions with cell membranes, allowing the detection of subtle differences between different cell types on the basis of cell surface features. Highly reproducible characteristic patterns were obtained from different cell types as well as from isogenic cell lines, enabling the identification of the cell type as well differentiating between normal, cancerous, and metastatic isogenic cell types with high accuracy.
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