4.8 Article

Copper-Catalyzed Intermolecular Oxidative [3+2] Cycloaddition between Alkenes and Anhydrides: A New Synthetic Approach to γ-Lactones

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 50, Pages 17652-17654

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja108073k

Keywords

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Funding

  1. National Natural Science Foundation of China [20625205, 20772034, 20932002]
  2. National Basic Research Program of China (973 Program) [2011CB808600]
  3. Ministry of Education of China [20090172110014]
  4. Guangdong Natural Science Foundation [10351064101000000]

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A new copper-catalyzed oxidative [3 + 2] cycloaddition of alkenes with anhydrides using oxygen as the sole oxidant to afford gamma-lactones has been developed. This catalyzed cyclization process has a broad substrate scope and affords gamma-lactones in good to excellent yields.

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