Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 48, Pages 17071-17073Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja107783j
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Funding
- Packard Foundation
- Sloan Foundation
- UC Berkeley
- Amgen
- Astra Zeneca
- Novartis
- National Institutes of Health [GM 79465, T32 GM066698]
- Stauffer fellowship
- NSF
- Royal Commission
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Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.
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