Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 35, Pages 12243-12245Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja1060406
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- Royal Society
- Leverhulme Trust [F/00204/AO, F/00204/AF]
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Introduction of prnA, the halogenase gene from pyrrolnitrin biosynthesis, into Streptomyces coeruleorubidus resulted in efficient in situ chlorination of the uridyl peptide antibotic pacidamycin. The installed chlorine provided a selectably functionalizable handle enabling synthetic modification of the natural product using mild cross-coupling conditions in crude aqueous extracts of the culture broth.
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