4.8 Article

Well-Defined DNA Nanoparticles Templated by Self-Assembled M12L24 Molecular Spheres and Binding of Complementary Oligonucleotides

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 45, Pages 15930-15932

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja108334g

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Funding

  1. JST
  2. Strategic International Cooperation Program (SICP)
  3. MEXT [21685007]
  4. Global COE Program Chemistry Innovation through Cooperation of Science and Engineering
  5. Grants-in-Aid for Scientific Research [21685007] Funding Source: KAKEN

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Perfectly monodisperse DNA nanoparticles were prepared via the self-assembly of 12 Pd(II) ions and 24 bidentate ligands functionalized with oligonucleotides of varying length (n = 1-3). The DNA nanoparticles formed hydrogen bonds with cDNA strands and an insoluble aggregate formed only with matching trimeric nucleotide strands (tri-A).

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