4.8 Article

General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A and C and (+)-12,12′-Dideoxychetracin A

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 41, Pages 14376-14378

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja106869s

Keywords

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Funding

  1. NIH-NIGMS [GM089732]
  2. National Defense Science and Engineering Graduate Fellowship
  3. Amgen
  4. Bristol-Myers Squibb
  5. DuPont

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A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report the first total synthesis of dimeric epitri- and epitetrathiodiketopiperazines.

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