4.8 Article

UV-Induced TA Photoproducts: Formation and Hydrolysis in Double-Stranded DNA

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 30, Pages 10260-10261

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja1023173

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Funding

  1. CNRS
  2. Region Champagne Ardenne
  3. Agence National pour la Recherche [ANR-07-PCVI-0004-01]
  4. Agence Nationale de la Recherche (ANR) [ANR-07-PCVI-0004] Funding Source: Agence Nationale de la Recherche (ANR)

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Hydrolysis of TA photoproduct leads to two derivatives presenting different formation kinetic profiles depending on the oligomer content. The formation efficiency of TA photoproducts in UV-C-irradiated DNA slightly exceeds the formation of the trans,syn cyclobutane pyrimidine dimer at TT sites.

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