Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 14, Pages 5010-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja1017046
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Funding
- National Institutes of Health (National Institute of General Medical Sciences) [R01-GM62871]
- Merck Research Laboratories
- Novartis
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A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary alpha-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon-carbon bond-forming process that generates potentially labile beta,gamma-unsaturated ketones with good enantioselectivity.
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