Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 132, Issue 20, Pages 6908-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja102571b
Keywords
-
Categories
Funding
- NSERC
- University of Ottawa
- Eli Lilly
- Amgen
- AstraZeneca
- Sloan Foundation
- OGS
Ask authors/readers for more resources
An external-oxidant-free process to access the isoquinolone motif via cross-coupling/cyclization of benzhydroxamic acid with alkynes is described. The reaction features a regioselective cleavage of a C-H bond on the benzhydroxamic acid coupling partner as well as a regioselective alkyne insertion. Mechanistic studies point out the important involvement of a N-O bond as a tool for C-N bond formation and catalyst turnover.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available