4.8 Article

Pd(II)-Catalyzed Olefination of Electron-Deficient Arenes Using 2,6-Dialkylpyridine Ligands

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 14, Pages 5072-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja900327e

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Funding

  1. Scripps Research Institute
  2. National Institutes of Health [NIGMS, 1 R01 GM084019-01A1]
  3. Amgen and Lilly
  4. A. P. Sloan Foundation

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Pd(II)-catalyzed meta-olefination of highly electron-deficient arenes is achieved through the use of a rationally designed mutually repulsive ligand. The combination of directed and nondirected C-H functionalization of arenes provides a versatile route for the synthesis of highly sought after 1,2,4-trisubstituted arenes.

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