4.8 Article

Gold Nanoparticles Functionalized with Gadolinium Chelates as High-Relaxivity MRI Contrast Agents

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 31, Pages 10828-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja904094t

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Funding

  1. Swiss NSF
  2. French Agence Nationale de la Recherche [ANR-07-JCJC-0040]
  3. Agence Nationale de la Recherche (ANR) [ANR-07-JCJC-0040] Funding Source: Agence Nationale de la Recherche (ANR)

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Water-dispersible gold nanoparticles functionalized with paramagnetic gadolinium have been fully characterized, and the NMRD profiles show very high relaxivities up to 1.5 T. Characterization using TEM images and dynamic light scattering indicate a particle size distribution from 2 to 15 nm. The gold cores of the nanoparticles do not contribute significantly to the overall magnetic moment.

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