Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 40, Pages 14184-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja906162u
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Funding
- NIGMS of the National Institutes of Health
- DARPA
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We demonstrate a new enzyme-induced disassembly of amphiphilic nanocontainers based on dendrimers. Disassembly and the ensuing release of noncovalently bound guest molecules are of great interest because of their implications in areas such as drug delivery and sensing. Achieving these with a protein as the stimulus is of even greater importance, because proteins are the primary indicators of biological imbalances. We achieved disassembly of the nanocontainers by disturbing the hydrophilic-lipophilic balance in the amphiphilic dendrimer building blocks.
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