4.8 Article

Metal-Bronsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 20, Pages 6967-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja9021683

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Funding

  1. Research Councils UK
  2. Astra-Zeneca
  3. EPSRC
  4. Pfizer

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Direct reductive amination of a wide range of ketones has been accomplished by the cooperative catalysis of an Ir(III)-diamine complex and a chiral phosphoric acid or its conjugate base.

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