Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 34, Pages 12050-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja904380q
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- NSERC
- University of Ottawa
- Eli Lilly
- Amgen
- Astra Zeneca
- Sloan Foundation
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A general. rhodium-catalyzed oxidative coupling reaction between internal alkynes and aryl aldimines is described. This process affords 3,4-disubstituted isoquinolines in good yield and high regioselectivity. Preliminary mechanistic studies suggest that the C-N bond formation arises from the reductive elimination of a rhodium(III) species.
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