Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 37, Pages 13240-13241Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja905539h
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Funding
- Universities of Leicester and Bristol
- Nuffield Foundation
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A general concept for designing self-assembling peptide fibrillar nano- to microstructures is described. The approach relies on the use of straightforward alpha-helical one-heptad (similar to 1 nm) modules without the need for more-specific designs. Various combinations of the modules gave a variety of constructs that were examined by a combination of spectroscopy and microscopy. These show that simple rearrangements and stereochemical conversions of the modules within similar templates Lead to different fiber morphologies. The concept opens new strategies for designing fibrous materials with tunable properties at the nanoscale.
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