Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 4, Pages 1386-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja809023n
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Funding
- MEXT, Japan [20350038]
- Grants-in-Aid for Scientific Research [20350038] Funding Source: KAKEN
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A single nucleotide potymorphism (SNP) base on the target is displayed at a gap in a ternary duplex carrying B-cyclodextrin-modified DNA. A stable tandem duplex forms regardless of the type of SNP base. A nucleobase-specific ligand is then added to this system. The dansyl moiety in the ligand is expected to form a luminous inclusion complex with nearby B-CyD, only when the ligand recognizes the specific base displayed in the gap.
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