Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 12, Pages 4434-4438Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja808827g
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Funding
- Council of Hong Kong [CityU 101608]
- Innovation & Technology Commission [ITS/029/08]
- 863 project [2006AA03Z302]
- NSFC [20725516]
- National Basic Research Program of China [2006CB93000, 2007CB936000]
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We report a novel kind of oxidized silicon nanospheres (O-SiNSs), which simultaneously possess excellent aqueous dispersibility, high photoluminescent quantum yield (PLQY), ultra photostability, wide pH stability, and favorable biocompatibility. Significantly, the PLQY of the O-SiNSs is as high as 25%, and is stable under intense UV irradiation and in acidic-to-basic environments covering the pH range 2-12. To our best knowledge, it is the first example of water-dispersed silicon nanoparticles which possess both high PLQY and robust pH stability suitable for broad utility in bioapplications. Furthermore, the O-SiNSs are readily conjugated with antibody, and the resultant O-SiNSs/antibody bioconjugates are successfully applied in immunofluorescent cell imaging. The results show that the highly luminescent and stable O-SiNSs/antibody bioconjugates are promising fluorescent probes for wide-ranging bioapplications, such as long-term and real-time cellular labeling.
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