Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 34, Pages 12076-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja9055245
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- NSFC
- MOST
- CAS
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TMG-chitotriomycin, a potent and selective inhibitor of the B-N-acetylglucosarninidases that possesses an unique N,N,N-trimethyl-D-glucosamine (TMG) residue, is revised to be the TMG-B-(1 -> 4)-chitotriose instead of the originally proposed alpha-anomer via its total synthesis, for which a highly convergent approach was developed in which the sterically demanding (1 -> 4)-glycosidic linkages are efficiently constructed by the Au(I)-catalyzed glycosylation protocol with glycosyl o-hexynylbenzoates as donors.
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