Synthesis of Epoxides by Palladium-Catalyzed Reactions of Tertiary Allyl Alcohols with Aryl or Alkenyl Halides

A novel synthetic method for the preparation of tri- or tetrasubstituted epoxides is reported. Treatment of readily available tertiary allyl alcohol with aryl or alkenyl, halide under palladium catalysis resulted in arylative cyclization to form the epoxide. The reaction includes intramotecular C-O bond and intermolecular C-C bond construction.