4.8 Article

Isolation of Notoamide E, a Key Precursor in the Biosynthesis of Prenylated Indole Alkaloids in a Marine-Derived Fungus, Aspergillus sp.

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 11, Pages 3834-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja810029b

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology of Japan [18032033, 19310140]
  2. Natio Foundation and the Keimeikai Foundation for Pharmaceutical Sciences
  3. NIH [CA70375]
  4. Grants-in-Aid for Scientific Research [18032033, 19310140] Funding Source: KAKEN

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Notoamide E was identified to be a short-lived precursor in the biosynthesis of prenylated indole alkaloids in the mussel-derived Aspergillus sp. In addition, the feeding experiment of the C-13-labeled notoamide E afforded structurally novel metabolites.

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