Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 11, Pages 3826-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja809702n
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- MEXT, Japan [20350038]
- Grants-in-Aid for Scientific Research [20350038] Funding Source: KAKEN
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A simple and easy method for stabilizing DNA triptexes using Ag(+) is reported. A silver ion displaces the N3 proton of cytosine in Hoogsteen base-pairing to form the base triplet CG.CAg(+). By the addition of an equimolar amount of Ag(+), the third-strand 15-mer sequence containing five cytosines was stabilized by similar to 30 degrees C in melting temperature at pH 7. The triplex structure was stable even under weakly basic conditions.
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