Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 41, Pages 14608-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja905336p
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Funding
- Government of Ontario
- Merck Frosst Center for Therapeutic Research
- NSERC
- CFI
- OIT
- University of Waterloo Aaron M. Dumas
- University of Waterloo
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The enantiosetective alkynylation of benzylidene Meldrum's acids has been successfully achieved through rhodium-catalyzed addition of TMS-acetylene in the presence of bisphosphine ligand 3,5-Xylyl-MeOBIPHEP. The resulting Meldrum's acids were obtained in good yields and up to 99% enantiomeric excess. The alkynylation method is carried out under mild reactions conditions and is compatible with an array of functional groups.
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