4.8 Article

Iron-Catalyzed Asymmetric Aerobic Oxidation: Oxidative Coupling of 2-Naphthols

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 17, Pages 6082-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja901391u

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Funding

  1. Ministry of Education, Science, and Culture, Japan [18002011]
  2. Grants-in-Aid for Scientific Research [18002011] Funding Source: KAKEN

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Fe(salan) complexes were found to be efficient catalysts for the asymmetric aerobic oxidative coupling of 2-naphthol. derivatives. This reaction can be carried out in air at 60 degrees C with high enantioselectivity up to 97% ee. This is the first report for asymmetric aerobic oxidation using molecular oxygen in air in the absence of additives.

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