Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 11, Pages 3818-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja8091399
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Funding
- National Science Foundation CAREER award [MCB 0644278]
- Rackham Predoctoral Fellowship from the University of Michigan
- Rackham International Student Fellowship
- Rackham Faculty Research Grant
- University of Michigan
- Sloan Fellowship from the Alfred P. Sloan Foundation
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We present an off-resonance carbon R-1 rho NMR experiment utilizing weak radiofrequency fields and selective polarization transfers for quantifying chemical-exchange processes in nucleic acids. The experiment extends the range of accessible time scales to similar to 10 ms, and its time-saving feature makes it possible to thoroughly map out dispersion profiles and conduct measurements at natural abundance. The experiment unveiled microsecond-to-millisecond exchange dynamics in a uniformly labeled A-site rRNA and in unlabeled, damaged DNA that would otherwise be difficult to characterize by conventional methods.
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