Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 23, Pages 8102-8107Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja900225w
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Funding
- Max Planck Society
- ANPCyT
- CONICET
- UBACyT
- DFG Center for Molecular Physiology of the Brain (DFG CMPB)
- Cluster of Excellence 171 of the CMPB
- UBA
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Quantum dots multifunctionalized with the amyloid protein (x-synuclein act at nanomolar concentrations as very potent inducers of the aggregation of micromolar-millimolar bulk concentrations of the protein in vitro and in cells. Fibrillation in live cells, a process diagnostic of Parkinson's disease, is accelerated up to 15-fold with only similar to 100 nanoparticles. The combination with a tetracysteine-tagged form of alpha-synuclein specific for fluorogenic biarsenicals constitutes a very sensitive system for studying pathological amyloid formation in cells.
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