Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 40, Pages 14237-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja9015638
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Funding
- Institute for Collaborative Biotechnologies (ICB) [19-0-D-0004]
- U.S. Army Research Office, and Lawrence Livermore National Laboratories through a UCDRD
- Corning Inc. Foundation Fellowship
- [T32AI07471]
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We present two strategies for attaching self-assembled DNA arrays to the surfaces of cells. Our first approach uses biotin-streptavidin interactions to bind DNA architectures to biotinytated cells. The second approach takes advantage of specific antibody-cell surface interactions, conjugated arrays and the subsequent binding to native epidermal growth factor receptors expressed on cancer cells. DNA array-cell surface interactions were visualized by fluorescence, confocal microscopy, and scanning electron microscopy. This novel application of DNA nanoarrays provides strategies to specifically label cell surfaces with micrometer-sized patches, bind cells onto a designed functionalized DNA scaffold, engineer cell/cell networks into microtissues, and deliver materials to cell surfaces.
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