4.8 Article

Thio FCMA Intermediates as Strong Acyl Donors: A General Solution to the Formation of Complex Amide Bonds

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 36, Pages 12924-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja906005j

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Funding

  1. NIH [CA103823]

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Novel methodology for the formation of amide bonds under neutral conditions is described. Evidence is presented that the active acyl donors are thio FCMA intermediates, generated from the reactions of thioacids with isonitriles.

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