Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 34, Pages 12064-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja901231w
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- The Netherlands Organization for Scientific Research (NWO)
- The Netherlands Proteomics Centre (NPC)
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Cytosolic and nuclear proteins may be subject to both O-GlcNAcylation and proteasomal degradation. By means of activity-based profiling, we demonstrate that O-GlcNAc serine-containing peptide epoxyketones bind to the proteasome catalytic active sites and thus provide the first clear evidence that proteasomes recognize peptides post-translationally modified with a GlcNAc moiety.
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