4.8 Article

Kinetically Controlled Self-Assembly of DNA Oligomers

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 7, Pages 2422-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja807765v

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Funding

  1. BBSRC
  2. EPSRC
  3. MRC
  4. MoD through the UK Bionanotechnology IRC
  5. Rhodes Trust
  6. NanoCore
  7. EPSRC [EP/G037930/1] Funding Source: UKRI
  8. Engineering and Physical Sciences Research Council [EP/G037930/1, GR/A10274/01] Funding Source: researchfish

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Metastable two-stranded DNA loops can be assembled into extended DNA oligomers by kinetically controlled self-assembly. Along the designed reaction pathway, the sequence of hybridization reactions is controlled by progressively revealing toeholds required to initiate strand-displacement reactions. The product length depends inversely on seed concentration and ranges from a few hundred to several. thousand base-pairs.

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