Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 38, Pages 13610-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja9027023
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Funding
- NSF [PHY0750049, OCE-0428900]
- NIGMS [GM073104]
- NIH [GM62159]
- Humboldt Foundation
- LJIS program
- Taiwan Merit Scholarships Program
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A microfluidic device made of polydimethylsiloxane (PDMS) addresses key limitations in single-molecule fluorescence experiments by providing high dye photostability and low sample sticking. Photobleaching is dramatically reduced by deoxygenation via gas diffusion through porous channel watts. Rapid buffer exchange in a laminar sheath flow followed by optical interrogation minimizes surface-sample contacts and allows the in situ addition and combination of other reagents.
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