Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 34, Pages 12091-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja902777d
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Funding
- Leukemia and Lymphoma Society
- NIH [CA125033, GM65500]
- NSF [0320783, 0821508]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0821508, 0320783] Funding Source: National Science Foundation
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Fluorinated lipids get rapidly internalized into living cells and are also displayed on the cell surface. The uptake of lipids is energy dependent and is likely via the clathrin-mediated endocytic pathway. Fluorinated lipids are 3-5-fold more efficient in acting as molecular transporters of noncovalently bound proteins than their hydrocarbon counterparts. These materials could serve as efficient molecular transporters for molecules that function in the cytoplasm such as short interfering RNAs (siRNAs)
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