Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 10, Pages 3432-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja809175q
Keywords
-
Categories
Funding
- NSF [0644865]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0644865] Funding Source: National Science Foundation
Ask authors/readers for more resources
A label-free, multiplexed DNA assay using fluorescent conjugated polymers as a detection probe to illustrate hybridization on metallic striped nanorods is demonstrated. Different DNA capture probes were encoded by the different reflectivities of Au and Ag stripe patterns. Successful DNA hybridization induced an optically detectable conformational change in conjugated polythiophene derivatives from forming single-stranded DNA-polymer complexes to forming double-stranded DNA-polymer ones. The results show attomole detection sensitivity and single-mutation specificity comparable to those of single-element assays but with much improved throughput.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available