Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 10, Pages 3464-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja900155x
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM073932-04, R01 GM073932, R01 GM074774] Funding Source: Medline
Ask authors/readers for more resources
The first transition metal catalyzed asymmetric carboalkoxylation reaction of propargyl esters is described. The (R)-MeO-DTBM-BIPHEP(AuCl)(2)-catalyzed reactions allow for the construction of benzopyrans containing quaternary stereocenters with excellent enantioselectivity. Experimental evidence supports a mechanism proceeding via the generation of a stabilized carbocation from an allylic oxonium intermediate and subsequent trapping by a chiral allylgold(I) spieces.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available