4.8 Article

Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Enamines

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 131, Issue 4, Pages 1366-+

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ja808358r

Keywords

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Funding

  1. National Natural Science Foundation of China [20532010, 20572049, 20721062]
  2. Major Basic Research Development Program [2006CB806106]
  3. Ministry of Education of China [1306005]

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The first highly enantioselective iridium-catatyzed hydrogenation of cyclic enamines has been developed. This new reaction provided an efficient method for the synthesis of optically active cyclic tertiary amines including natural product crispine A.

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